کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6372172 1319970 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Some conceptual thoughts toward nanoscale oriented friction in a model of articular cartilage
ترجمه فارسی عنوان
برخی اندیشه های مفهومی نسبت به اصطکاک نانو ذرات در یک مدل غضروف مفصلی
کلمات کلیدی
روانکاری و پوشیدن مفصل غضروف، فسفولیپید های سطح فعال، هیالورونان، هدایت پروتون،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


- Clinical remarks of articular cartilage function matched with a model of lubrication.
- Proton management strategies are common biologic functions.
- AC utilizes proton motion to manage interfacial lubrication with amphiphilic molecules.
- Model supports clinical phenomena associated with proton motion at the surface of AC.
- Some of those phenomena are designed for clinical therapeutics.

This work presents a conceptual framework as to how a deficit in the synovial-fluid content, exemplified by hyaluronan or any other amphiphilic species, is capable of decisively altering the complex lubrication and wear conditions observed clinically in articular cartilage. The effect is revealed in (non)stationary regimes if the cartilage is subjected to some normal periodic load, revealing over its exploitation time increasingly dissipative, in general entropy-addressing, characteristics. It can be hypothesized that a Grotthuss-type proton transport physiology-concerning mechanism in channel-like, phospholipid-water cartilage's articulating nanospaces will be responsible for the expression of the lubrication mode. The corresponding wear involving overall change is then manifested adequately in the stationary regime, and in a viable system-parametric correlation with its lubrication counterpart. Certain analytic formulae for the nanoscale oriented coefficient of friction, involving generically H-bonds breaking mechanism, and pointing to some local-viscosity context, have been proposed for fitting the experimental data and clinical observations involving proton management at articular cartilage surfaces.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 244, Issue 2, August 2013, Pages 188-200
نویسندگان
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