Clinical perineural invasion of cutaneous head and neck cancer: Impact of radiotherapy, imaging, and nerve growth factor receptors on symptom control and prognosis

Article ID	Journal	Published Year	Pages	File Type
10008390	Oral Oncology	2018	8 Pages	PDF

Abstract

Positive TrkA and/or CD271 staining predicts worse outcomes. Patients may benefit from aggressive RT for local control and symptom improvement. Future research is needed to identify the potential for anti-nerve growth factor therapies in CPNI.

Keywords

Trk A NGFR FOXP3 IPNI SCC Crt LRR BCC NED CSM PNI MRI Imaging Magnetic resonance imaging computed tomography forkhead box P3 Perineural invasion Radiotherapy Immunohistochemical staining Skin cancer Head and neck cancer Chemoradiotherapy Surgery Locoregional recurrence nerve growth factor Cancer-specific mortality no evidence of disease Basal cell carcinoma Squamous cell carcinoma Symptom control nerve growth factor receptor

Related Topics

Health Sciences Medicine and Dentistry Dentistry, Oral Surgery and Medicine

Preview

Clinical perineural invasion of cutaneous head and neck cancer: Impact of radiotherapy, imaging, and nerve growth factor receptors on symptom control and prognosis

Authors

Jie Jane Chen, Jeremy P. Harris, Christina S. Kong, John B. Sunwoo, Vasu Divi, Kathleen C. Horst, Sumaira Z. Aasi, S. Tyler Hollmig, Wendy Y. Hara,