Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10021717 | The Journal of Emergency Medicine | 2005 | 7 Pages |
Abstract
Our study compared levalbuterol (LEV) to the combination of racemic albuterol (RAC) and ipratropium bromide (IB) in 140 patients aged 6-18 years presenting to a tertiary hospital Emergency Department with acute asthma and a peak expired flow rate (PEF) < 80% predicted. Patients were randomized to: LEV (⤠6 nebs LEV 1.25 mg); or RAC/IB (⤠3 nebs RAC 5.0 mg + IB 0.25 mg followed as needed by ⤠3 nebs RAC 5.0 mg). No difference was noted in the study population (mean age 11.6 years and initial mean predicted PEF 49.5%) between LEV (n = 72) and RAC/IB (n = 68) for study outcomes except for measures of heart rate (HR). Median % HR increase for RAC/IB (26%) exceeded LEV (9%) (p < 0.001). In a sample of children with acute asthma and initial mean PEF < 50% predicted, LEV was associated with less tachycardia but had no other advantage over RAC combined with IB.
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Authors
Mark E. MD MPH, Michael S. MD, Kenneth R. MD, Timothy J. MD, Timothy A. MD, Shane M. MD,