Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10027997 | International Journal of Antimicrobial Agents | 2005 | 6 Pages |
Abstract
The molecular mechanism of high level tetracycline resistance in T serotypes 4 and 11 group A streptococcal (GAS) isolates was examined in 61 tetracycline-resistant isolates in Japan. PCR and sequencing analyses revealed that the T serotype/emm genotype, T4/4 isolates carried tet(O) genes, which were genetically homogenous. The T11/11 and T11/89 isolates carried different subtypes of tet(M) genes, which were present on transposons Tn916 and Tn1545, respectively. In addition, these T11 isolates may have obtained the tet(M) gene after the 1990s, because resistance to tetracycline in T11 isolates was rarely found before then. These results strongly suggested that the T4 and T11 GAS isolates acquired tetracycline-resistance via different molecular mechanisms.
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Authors
Masakado Matsumoto, Kenji Sakae, Michio Ohta, Miyoko Endo, Rumi Okuno, Shoko Murayama, Kyoko Hirasawa, Rieko Suzuki, Junko Isobe, Daisuke Tanaka, Chihiro Katsukawa, Aki Tamaru, Masaaki Tomita, Kikuyo Ogata, Tomihisa Yasuoka, Tadayoshi Ikebe,