Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10030575 | Transactions of the Royal Society of Tropical Medicine and Hygiene | 2005 | 8 Pages |
Abstract
We conducted a randomized open trial of oral chloramphenicol (50Â mg/kg/day in four divided doses for 14 days) versus ofloxacin (15Â mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (PÂ <Â 0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.
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Authors
Simmaly Phongmany, Rattanaphone Phetsouvanh, Siho Sisouphone, Chirapha Darasavath, Pankham Vongphachane, Oudayvone Rattanavong, Mayfong Mayxay, Andrew C. Ramsay, Stuart D. Blacksell, Chanpheng Thammavong, Bounkong Syhavong, Nicholas J. White,