| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10032082 | American Journal of Obstetrics and Gynecology | 2005 | 8 Pages |
Abstract
TLR-4 protein expression is increased in interstitial trophoblasts of patients with preeclampsia. We propose that “danger signals” at the feto-maternal interface, which are recognized by trophoblasts through TLR-4, may play a key role in the creation of a local abnormal cytokine milieu. This suggests a novel mechanism that links the activation of the innate immune system through TLR-4 and preeclampsia.
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Authors
Yeon Mee MD, Roberto MD, Seo Young BS, Chong Jai MD, PhD, Brian A. BS, D. Randall PhD, Jyh Kae MD, Ricardo MD, Moshe MD, Shigeru MD, Vikki M. PhD, Gil MD, PhD,