| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10032533 | American Journal of Obstetrics and Gynecology | 2005 | 6 Pages |
Abstract
Hyperglycemia-induced embryopathy involves apoptosis, during which the expression of proapoptotic protein Bax is upregulated and the activity of the cell-survival factor, Akt kinase, is decreased in yolk sac cells. These observations suggest that hyperglycemia of maternal diabetes triggers apoptotic signaling pathways and inhibits cell survival pathways, leading to embryonic malformations.
Related Topics
Health Sciences
Medicine and Dentistry
Medicine and Dentistry (General)
Authors
E. Albert MD, PhD, MBA, Xiang-Dong MD, PhD, Zhiyong PhD, Ying-King MD, PhD, Danny PhD,