| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10051525 | The Journal of Urology | 2005 | 4 Pages |
Abstract
A sex disparity was observed in the Tgfbr2fspko mouse model lacking TGF-β signaling in fibroblasts. Deletion of TGF-β in males leads to a hypertrophied lamina propria and muscularis externa with myofibroblast differentiation and proliferation. Female homozygous Tgfbr2fspko bladders appeared the same as those of wild-type male and female controls. This model suggests a role for stromal TGF-β signaling with estrogens and androgens in bladder fibrosis.
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Authors
ALI-REZA SHARIF-AFSHAR, JEFFREY M. DONOHOE, JOHN C. IV, MARK C. ADAMS, JOHN W. III, NEIL A. BHOWMICK,