Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10052046 | The Journal of Urology | 2005 | 4 Pages |
Abstract
Loss of E-cadherin expression correlates with loss of intercellular adhesion, tight junction formation and enhanced paracellular transport. The data show that E-cadherin hampers the permeation of hypericin in spheroids and the loss of intercellular adhesion, present in superficial bladder cancer lesions, can be associated with enhanced hypericin permeation. Therefore, E-cadherin expression seems to have a pivotal role in the selective uptake of hypericin after intravesical instillation in human bladders.
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Authors
ANN HUYGENS, APPOLINARY R. KAMUHABWA, TANIA ROSKAMS, BEN VAN CLEYNENBREUGEL, HENDRIK VAN POPPEL, PETER A.M. de WITTE,