Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10064793 | European Journal of Obstetrics & Gynecology and Reproductive Biology | 2005 | 4 Pages |
Abstract
Objective: To determine the safety and effectiveness of managing intrauterine death after 24 weeks gestation using a combination of mifepristone and misoprostol. Study design: Two regimens are compared. Twenty-nine women (group one) were managed using a combination of oral mifepristone and vaginal/oral misoprostol. After a change in dosage and route of administration, a further 20 women were managed with oral mifepristone and vaginal misoprostol (group two). Results: All women delivered vaginally. The mean induction to delivery interval in group one was 7Â h compared with 10.2Â h in group two. Group two experienced fewer gastrointestinal side-effects than group one. Conclusion: This study confirms that the combined use of mifepristone and misoprostol is a safe and effective way of managing IUD after 24 weeks gestation. Regimen one results in a shorter induction to delivery interval but is associated with a higher incidence of gastrointestinal side-effects.
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Authors
Tara E. Fairley, Maureen Mackenzie, Philip Owen, Fiona Mackenzie,