Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10070299 | Taiwanese Journal of Obstetrics and Gynecology | 2005 | 9 Pages |
Abstract
Chemotherapy is a major treatment modality for ovarian cancer, but chemoresistance is a clinical problem that compromises the efficiency of treatment and finally results in treatment failure. The development of resistance to chemotherapeutic agents might be related to multiple mechanisms such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, and increased tolerance to drug-induced DNA damage. This article is a summary of the various mechanisms that are involved in chemoresistance in ovarian cancer.
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Authors
Kar-San Ling, Gin-Den Chen, Horng-Jyh Tsai, Maw-Sheng Lee, Po-Hui Wang, Fu-Shing Liu,