Article ID Journal Published Year Pages File Type
10070299 Taiwanese Journal of Obstetrics and Gynecology 2005 9 Pages PDF
Abstract
Chemotherapy is a major treatment modality for ovarian cancer, but chemoresistance is a clinical problem that compromises the efficiency of treatment and finally results in treatment failure. The development of resistance to chemotherapeutic agents might be related to multiple mechanisms such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, and increased tolerance to drug-induced DNA damage. This article is a summary of the various mechanisms that are involved in chemoresistance in ovarian cancer.
Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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