Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10083411 | The Journal of Hand Surgery | 2005 | 6 Pages |
Abstract
Our findings show that adenovirus-based gene therapy is an efficient means of gene delivery to rabbit flexor tendons. Transduction efficiency of transgenes was dose dependent across the tested titers, although adenovirus-induced inflammation was notable only at the highest titer. This indicates that efficient gene transfer without notable local inflammatory response may be achieved by using the lower titers. Although adenovirus-induced inflammation can be minimized by using lower viral titers, its impact on adhesion formation in the long term remains unknown.
Related Topics
Health Sciences
Medicine and Dentistry
Orthopedics, Sports Medicine and Rehabilitation
Authors
Vishal MD, Quan MD, Jeffrey MD, Tong-Chuan MD, PhD, Rex C. MD, PhD, Daniel P. MD,