| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10086424 | American Journal of Otolaryngology | 2005 | 6 Pages |
Abstract
Promoter hypermethylation of hMLH1, MGMT, and p16 genes was commonly detected in 47 SCCHN cases with up to 65% showing aberrant promoter hypermethylation in at least 1 gene. Promoter hypermethylation of 2 or 3 genes was significantly associated with increased 2-year disease-free survival, suggesting that promoter hypermethylation of multiple genes might improve survival. Significant correlation was also noted between a positive alcohol use history and promoter hypermethylation of the MGMT gene with no promoter hypermethylation of the p16 gene.
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Authors
Sajeev K. MD, Lingbao MD, Chun-Yang MD, Ehab MD,