| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10091394 | The Journal of Pediatrics | 2005 | 4 Pages |
Abstract
The diminished expansion of T and B lymphocytes strongly suggests that a disturbance in the adaptive immune system is intrinsically present in DS and is not a reflection of precocious aging. Thymic alterations have been described in DS that could explain the decreased numbers of T lymphocytes, but not the striking B lymphocytopenia, seen in these children.
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Authors
Yvette C.M. PhD, Petrus W. MD, Eugenie F.A. Bsc, André B. MD, PhD, Wim C.J. Msc, PhD, Frank MD, PhD, Esther MD, PhD,