Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10091867 | The Journal of Pediatrics | 2005 | 6 Pages |
Abstract
We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological investigation of 121 children with cavernous transformation of the portal vein seen between 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum aminotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intra- and/or extrahepatic bile ducts. Surgical decompression of the portal system (portal-systemic or Rex anastomosis) resulted in the regression of the signs of cholestasis in all children. We conclude that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernoma.
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Authors
Marion MD, Stéphanie MD, Frédéric MD, Monique MD, Danièle MD, Olivier MD,