Adenosine Actions are Preserved in Corpus Cavernosum from Obese and Type II Diabetic db/db Mouse

Results from this study suggest that corpora cavernosa from obese and diabetic db/db mice display altered neural-mediated responses that would favor penile detumescence, i.e., increased contractile response to adrenergic nerve stimulation and decreased relaxant responses upon activation of NANC nerves. However, increased cavernosal responses to adrenergic nerve stimulation are not due to impaired negative modulation of sympathetic neurotransmission by adenosine in this diabetic model. Carneiro FS, Giachini FRC, Lima VV, Carneiro ZN, Leite R, Inscho EW, Tostes RC, and Webb RC. Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.