| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10100434 | The Journal of Sexual Medicine | 2005 | 6 Pages |
Abstract
These findings emphasize the importance of NO/cGMP and EDHF pathways for normal erectile function. They also give support to the in vitro observation that diabetes impairs NO and EDHFâdependent responses, precluding the complete recovery of erectile function with PDE5 inhibitors and explaining the relatively poor clinical response of diabetic men with ED to PDE5 inhibition. Finally, our study suggests that a pharmacological approach that combines enhancement of NO/cGMP and EDHF pathways could be necessary to treat ED in many diabetic men.
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Authors
Javier PhD, Pedro MD, PhD, Sonia Gabancho, Rocio BSc, Sebastian MD, Iñigo MD,