| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10103519 | Journal of the American College of Surgeons | 2005 | 6 Pages |
Abstract
Polymerized hemoglobin attenuates lipopolysaccharide-stimulated expression of intercellular adhesion molecule-1 protein, which is associated with upregulation of the cytoprotective protein HO-1 in human pulmonary endothelial cells. This antiinflammatory effect offers a novel mechanism by which hemoglobin-based oxygen carrier solutions may be exploited therapeutically as resuscitative fluids.
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Authors
Aaron M. MD, Ernest E. (FACS), Jeffrey L. (FACS), Mark D. MD, Lihua BS, Peter K. Moore, Anirban PhD,