| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10103546 | Journal of the American College of Surgeons | 2005 | 7 Pages |
Abstract
Treated wounds from the early treatment group displayed delayed wound healing, with no reduction in scar hypertrophy. Later treatment of wounds with the same antibody, beginning 7 days after wounding, resulted in a reduction in scar hypertrophy. These results support our hypothesis and clearly demonstrate that TGF-β1, 2, and 3 have differential temporal effects during the wound-healing process, and are important for optimal wound healing in the first week after wounding; beyond 1 week, TGF-β1, 2, and 3 play a critical role in hypertrophic scar formation.
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Authors
Leonard MD, Alexandrina S. MD, W. Robert PhD, Nakshatra K. PhD, Jerome D. MD, Steven PhD, Thomas A. (FACS),