Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats

In conclusion, our findings show that centrally administered histamine increases plasma GnRH, LH, FSH and testosterone levels of conscious male rats without change any sperm parameters. Moreover, according to our findings, central histaminergic H1, and H2 receptors mediate these histamine-induced effects.