Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10106956 | Neuroscience Letters | 2018 | 13 Pages |
Abstract
LRRK2 is the most common genetic cause of PD. G2385R and R1628âP variants are the most common variants of LRRK2 in Chinese populations. Consensus on the clinical features of G2385R and R1628âP related PD has not been reached yet, although it had been widely studied. In our study, genotype analyses were conducted on 721 PD patients of Chinese origin. A total of 62 G2385R carriers, 32 R1628âP carriers and 623 idiopathic PD patients underwent the following clinical feature analysis. Motor symptoms, non-motor symptoms and co-morbidities were the targeted features to be analyzed. As a result, Neither the G2385R nor the R1628âP carriers showed significant clinical feature differences when compared to the idiopathic PD patients, so did the comparison between the G2385R and the R1628âP carriers. In conclusion, the clinical features of PD patients with LRRK2 G2385R or R1628âP variants were similar to those of idiopathic PD.
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Authors
Dongxiao Liang, Li Shu, Hongxu Pan, Qian Xu, Jifeng Guo, Xinxiang Yan, Beisha Tang, Qiying Sun,