Article ID Journal Published Year Pages File Type
10123450 British Journal of Anaesthesia 2005 6 Pages PDF
Abstract
Clearance in infants is approximately half that described in adults, suggesting immaturity of P450 CYP3A4 and CYP1A2 enzyme isoforms that metabolize levobupivacaine in infants. This lower clearance delays Tmax, which was noted to occur approximately 50 min after administration of caudal epidural levobupivacaine.
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Health Sciences Medicine and Dentistry Anesthesiology and Pain Medicine
Preview
Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age
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