Characterization, antioxidant and antiinflammation of mycelia selenium polysaccharides from Hypsizygus marmoreus SK-03

The synergistical action of inflammation response with oxidative stress has been reported to be response for the pathogenesis of lipopolysaccharide (LPS)-induced lung damage. In our present work, the antioxidative and anti-inflammatory efficacies of mycelia selenium polysaccharides (MSPS) from Hypsizigus marmoreus SK-03 in LPS-induced lung damaged mice, and its structure characterizations had been evaluated and analyzed. The animal investigations indicated that MSPS markedly ameliorated pulmonary injuries by the regulations of related inflammatory events via the observably antioxidant effects at the dose of 800 mg/kg. The characterizations showed that MSPS was a α- and β-configurational semi-crystalline polymer with small molecular weights, and expressed an integrated surface and regular shapes with homogeneous particles. Taken together, the current work demonstrated that MSPS might be a potentially effective candidate medicine for the treatment of lung damage and its complications.