Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10129368 | European Journal of Pharmacology | 2018 | 30 Pages |
Abstract
The amino acid tryptophan (2-Amino-3-(lH-indol-3-yl)-propanoic acid; Trp) is a precursor of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) that performs various brain functions. The administration of Trp is used in experimental studies to manipulate the serotonergic system, however the dose of Trp required to raise brain 5-HT levels is controversial. The aim of this study was to systemically review the effect of the administration of different doses of Trp on cerebral 5-HT levels. Two independent authors conducted a systematic review in the electronic databases. Twenty-five studies were included in the present review. Trp was administered orally, intraperitoneally or subcutaneous in adult animals. The brain 5-HT levels elevated after Trp administration in different intensities, dependent of the brain region evaluated and the time of administration. Further studies are needed to assess the dose-response of Trp administration to brain 5-HT levels.
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Authors
Isadora Braga Contreiras Carneiro, Ana Elisa Toscano, Diego Cabral Lacerda, Marcela de Sá Barreto da Cunha, Raul Manhães de Castro, Tereza Cristina Bonfim de Jesus Deiró, Jairza Maria Barreto Medeiros,