| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10129505 | Placenta | 2018 | 11 Pages |
Abstract
Intrauterine growth restriction (IUGR) is a serious pregnancy complication caused by placental insufficiency. We previously reported that truncation of MIMT1 gene exons 3 and 4 (MIMT1Del) causes IUGR in cattle. Here we investigated miRNA expression in the foetal and maternal placenta tissues of MIMT1Del/WT foetuses. Small RNA next generation sequencing and quantitative PCR revealed placental tissue-specific expression of the miR-4321, known to regulate many genes involved in early foetal development. This study also indicated that maternal and foetal components of the placenta respond differently to a deleterious conceptus mutation.
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Authors
Karolina Rutkowska, Monika Stachowiak, Jolanta Oprzadek, Stefan Bauersachs, Krzysztof Flisikowski,