| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10137876 | Diabetes Research and Clinical Practice | 2018 | 30 Pages |
Abstract
Our data provide evidence of a substantial different Zn homeostasis regulation between Znt8 Arg-325 and Trp-325 carriers in PBMCs from T2DM patients. Moreover, Znt8 Arg-325 risk variant shows an enhanced inflammatory response upon LPS stimulation that might aggravate insulin resistance and the progression of diabetes cardiovascular complications.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
R. Giacconi, M. Malavolta, L. Chiodi, G. Boccoli, L. Costarelli, A.R. Bonfigli, R. Galeazzi, F. Piacenza, A. Basso, N. Gasparini, L. Nisi, R. Testa, M. Provinciali,