Involvement of acetyl-CoA-producing enzymes in the deterioration of the functional potential of adipose-derived multipotent cells from subjects with metabolic syndrome

Article ID	Journal	Published Year	Pages	File Type
10137908	Metabolism	2018	42 Pages	PDF

Abstract

Adipo-subASCs may be more susceptible than adipo-visASCs to deterioration of the lipogenic, oxidative and antioxidant potential associated with metabolic syndrome. Intrinsic alterations in transcription levels of acetyl-CoA-producing enzymes may contribute to the metabolic reprogramming of adipo-subASCs from METS patients.

Keywords

SIRT5 APC COA MCD ACADM ACLY ATP citrate lyase ACACA Acss1 DGAT1 SREBF1 GGT CEBPα SOD3 Acss2 ACADVL PE-Cy7 ACADS diacylglycerol o-acyltransferase 1 RPL13A ribosomal protein L13A acyl-CoA dehydrogenase, very long chain HOMA-IR FOXO1 GPT PPARγ ASC FITC FBS CCAAT/enhancer binding protein α malonyl-CoA decarboxylase Small interfering RNA siRNA γ-glutamyltransferase allophycocyanin acetyl-CoA carboxylase alpha fatty acid synthase Adipose tissue GOT glutamic oxaloacetic transaminase Forkhead box O1 fetal bovine serum adipose tissue-derived mesenchymal stem cells Metabolic syndrome body mass index BMI sterol regulatory element binding transcription factor 1 phycoerythrin Fasn fluorescein isothiocyanate high-density lipoprotein cholesterol Lipogenesis METS HDL-cholesterol LDL-cholesterol Low-density lipoprotein cholesterol coenzyme A glutamate pyruvate transaminase peroxisome proliferator activated receptor γ