| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10138239 | Journal of Affective Disorders | 2019 | 28 Pages |
Abstract
Our preliminary results do not support a different baseline expression of NK1Rs in a representative sample of never-medicated patients with MDD during a current moderate/severe depressive episode. The modulatory effect of NK1Rs on affective symptoms is in line with early positive results on antidepressant action of NK1 antagonists. However, the effect is likely to be too weak for treatment of MDD with NK1R antagonists alone in clinical practice.
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Authors
Mikko Nyman, Olli Eskola, Jaana Kajander, Riitta Jokinen, Jukka Penttinen, Tomi Karjalainen, Lauri Nummenmaa, Jussi Hirvonen, Donald Burns, Richard Hargreaves, Olof Solin, Jarmo Hietala,