Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10138290 | Behavioural Brain Research | 2019 | 26 Pages |
Abstract
DPP4mut rats show blunted CORT response in line with their lower behavioral stress-response profile. These results are consistent with the hypothesis that increased central NPY levels elevate the threshold of stress response. We suggest that changes in the expression levels of key HPA axis genes (Nr3c1 and Fkbp5) are a consequence of the altered stress-perception of DPP4mut animals, thus further contributing to the stress-resilient phenotype.
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Authors
Yulia Golub, Eva-Maria Schildbach, Chadi Touma, Oliver Kratz, Gunther H. Moll, Stephan von Hörsten, Fabio Canneva,