Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10140898 | Food Chemistry | 2019 | 35 Pages |
Abstract
Betalains are nitrogenous plant pigments known for their high antioxidant capacity. For the first time, this antioxidant nature has been studied in an in vivo system using the model organism Caenorhabditis elegans. The oxidative stress caused in the fluorescent strain TJ375 (hsp-16.2::GFP) was reversed by the presence of both natural and semi-synthetic betalains, with an ED50 value around 25â¯Î¼M for betacyanins and up to 10â¯Î¼M for betaxanthins, with indicaxanthin, the major pigments in prickly pear fruits, as the most effective betalain. The effect of model betalains on the lifespan of the wild-type N2 strain was carefully studied using the automatic platform “Lifespan Machine”. In a search for different approaches to suppress progeny, pop-1 RNAi was used to avoid FUdR use. The presence of betalains in the medium, both as pure compounds and as enriched Opuntia extracts significantly increased the lifespan of C. elegans.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
M. Alejandra Guerrero-Rubio, Samanta Hernández-GarcÃa, Francisco GarcÃa-Carmona, Fernando GandÃa-Herrero,