Enabling quantification of protein concentration in human serum biopsies using attenuated total reflectance - Fourier transform infrared (ATR-FTIR) spectroscopy

This demonstrates that ATR-FTIR is able to quantify protein within clinically relevant complex matrices and concentrations, such as serum samples, rapidly and with simple sample preparation. The ability to provide a quantification step, along with rapid disease classification, from a spectroscopic signature will aid clinical translation of vibrational spectroscopy to assist with problems currently faced with patient diagnostic pathways.