Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10142567 | Journal of Environmental Radioactivity | 2018 | 7 Pages |
Abstract
Zebrafish were chronically exposed to Am-241, an alpha-emitting radionuclide via daily consumption of an enriched artificial diet. Am-241 uptake was quantified in Danio rerio after 5 and 21 days of exposure via daily Am-spiked food ingestion and after 21 days of exposure followed by 5 days of depuration. Americium accumulates mostly in digestive tract, muscle, rest of the body but the accumulation levels and trophic transfer rate (0.033-0.013%) were low. Corresponding cumulative doses were calculated for the whole body (9â¯mGy) and for the digestive tract (42â¯mGy) with internal alpha radiation contributing to more than 99% of the total dose. Genotoxic effects (gamma-H2AX assay) and differential gene expressions of main biological functions were examined. Although fish were exposed to a low dose rate of 13â¯Î¼Gyâ¯hâ1, DNA integrity and gene expression linked to oxidative stress, hormonal signaling and spermatogenesis were altered after 21 days of Am-241 exposure. These results underline the higher toxicity of alpha emitter Am-241, as compared to other studies on gamma radiation exposure.
Related Topics
Physical Sciences and Engineering
Energy
Nuclear Energy and Engineering
Authors
O. Simon, I. Barjhoux, V. Camilleri, B. Gagnaire, I. Cavalié, D. Orjollet, F. Darriau, S. Pereira, K. Beaugelin-Seillers, C. Adam-Guillermin,