Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10142881 | Maturitas | 2018 | 26 Pages |
Abstract
Platelet-rich plasma is an autologous and safe blood product containing a high concentration of platelets and leucocytes. Platelets, growth factors, leucocytes and plasma are fundamental fibroblast proliferation agents. Leucocytes' plasticity, reparative qualities, cross-talk between cells and capacity to orchestrate diverse outcomes are receiving considerable research attention. Fibroblasts are able to migrate and proliferate into the tissue surrounding a wound and subsequently deposit granulation tissue, which minimises scarring. Fibroblasts also have anti-ageing benefits. Elucidation of the role of leucocytes in tissue repair has led to a new approach to tissue regeneration and the formation of a new therapeutic modality, namely immuno-regenerative medicine.
Keywords
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Ageing
Authors
Jeannie Devereaux, Kulmira Nurgali, Dimitrios Kiatos, Samy Sakkal, Vasso Apostolopoulos,