Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10143893 | Critical Reviews in Oncology/Hematology | 2018 | 10 Pages |
Abstract
This meta-analysis aims to determine the long-term oncological outcomes of SEMS as bridge to surgery (BTS) versus emergency surgery (ES). A systematic search without restrictions was conducted, and all studies comparing SEMS with ES reporting on long-term outcomes were included. Methodological quality was assessed using the appropriate tools. Twenty-one comparative studies were selected, reporting on 1919 patients. Meta-analysis showed no significant difference regarding three- and five-year overall survival (ORâ=â0·85 (0·68-1·08) and ORâ=â1·04 (0·68-1·57), respectively), disease-free survival (ORâ=â0·96 (0·73-1·26) and ORâ=â0·86 (0·54-1·36), respectively) and local recurrence rate (ORâ=â1·32 (0·78-2·23)). Permanent stomas were significantly lower in the SEMS group (OR 0·49 (0·32-0·74)). Sensitivity analysis on three-year survival showed opposite outcomes, with a trend towards worse survival in the SEMS group when only RCTs are taken into account. In conclusion, when in experienced hands, SEMS placement as BTS seems oncologically safe.
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Authors
Femke J. Amelung, Thijs A. Burghgraef, Pieter J. Tanis, Jeanin E. van Hooft, Frank ter Borg, Peter D. Siersema, Willem A. Bemelman, Esther C.J. Consten,