Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10148116 | Journal of the Neurological Sciences | 2018 | 8 Pages |
Abstract
Pre-fibrillar amyloid precursors appear to play a pivotal role during the initial phase of amyloid fibril formation. The mechanical distortion and subsequent atrophy of Schwann cells resulting from the elongation of amyloid fibrils may be related to small-fiber predominant loss, which is a classical characteristic of amyloid neuropathy. Although rather rare, the destruction of myelin (i.e., demyelination) resulting from amyloid deposition may relate to nerve conduction abnormalities mimicking chronic inflammatory demyelinating polyneuropathy.
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Authors
Haruki Koike, Ryoji Nishi, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Takeo Sakurai, Takayoshi Shimohata, Masahisa Katsuno, Gen Sobue,