A gene expression profile associated with perineural invasion identifies a subset of HNSCC at risk of post-surgical recurrence

Article ID	Journal	Published Year	Pages	File Type
10148632	Oral Oncology	2018	8 Pages	PDF

Abstract

PNI is characterised by a specific gene expression profile and distinct biological characteristics. Analysing the PNI gene expression profile holds potential for therapeutic stratification of HNSCC and identification of a subset of tumours with a higher risk of recurrence.

Keywords

CPE RPPA HNSCC TCGA PNI DFS mTOR FDR ECs reverse phase protein array Ali The cancer genome atlas Disease free survival overall survival Gene expression Positive surgical margin Perineural invasion false discovery rate mammalian target of rapamycin Gene ontology Head and neck squamous cell carcinoma Extracapsular spread