Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10153605 | Neurobiology of Learning and Memory | 2018 | 7 Pages |
Abstract
Our findings show that exposure to the elevated platform differentially affects the induction of LTP in adult and juvenile animals. Specifically, whereas exposure to stress resulted in impaired LTP in adult animals, it resulted in enhanced LTP in juvenile animals. Similarly, while MK801 failed to inhibit the induction of LTP in both age groups, it resulted in inhibition of stress-induced enhanced LTP in juvenile animals, but did not affect stress-induced impaired LTP in adult animals. Taken together, these findings demonstrate that emotional metaplasticity is differently dependent on NMDAr in adult and juvenile animals that may stem from developmental differences in the NMDA receptor representation. These results further confirm that the mechanisms of plasticity following stress are distinctive in the two groups of age.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Tala Khazen, Kuldeep Shrivastava, Reem Jada, Ossama A. Hatoum, Mouna Maroun,