The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats

Article ID	Journal	Published Year	Pages	File Type
10153635	Neurobiology of Learning and Memory	2018	10 Pages	PDF

Abstract

Our findings show that metaplastic changes induced by NMDA receptors blockade affected sucrose instrumental memory retrieval as shown by both behavioural and molecular changes. We hypothesize that these findings however suggested a switch to extinction rather than a reconsolidation.

Keywords

zif268 i.p.TBS mTOR NAC MK-801 BLA NACs PFA HEPES PMSF NMDAR PBS DAB FR1 TSF TIF AMPAR 3,3-diaminobenzidine 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid CeA ERK1/2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ALP Amygdala Akt AMY Extinction Reconsolidation Retrieval Context analysis of variance ANOVA Tris-buffered saline long-term potentiation LTP RET standard error of mean self-administration intraperitoneal time-out horse serum phenylmethylsulfonyl fluoride metaplasticity Phosphate-buffered saline SEM Rat mammalian target of rapamycin Nucleus accumbens nucleus accumbens shell central nucleus of amygdala paraformaldehyde protein kinase B Extracellular signal-regulated kinases 1/2 N-methyl-d-aspartate receptor instrumental learning