| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10154492 | Journal of Pharmaceutical and Biomedical Analysis | 2019 | 6 Pages |
Abstract
In the development of new pharmaceutical formulations it is important to consider the possible interactions between the active pharmaceutical ingredient (API) and excipients which is a well-known problem. The objective of the work presented here was to investigate such reactions by means of diffusion ordered NMR spectroscopy (DOSY). The known reaction of 5-aminosalicylic acid (5-ASA) and the excipient citric acid was studied. Three reaction products have been verified by DOSY, 1H NMR and HPLC measurements. Despite a poor separation in the DOSY diagram, the reaction products could be assign due to the processing of thoughtful selected parts of the signals. The reaction of 5-ASA with formic acid and benzocaine with dibutyl phthalate was also studied by means of DOSY experiments.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Alexander Becht, Curd Schollmayer, Johannes Wiest, Detlef Heller, Wolfgang Baumann, Helmut Buschmann, Ulrike Holzgrabe,