Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10156636 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 10 Pages |
Abstract
The present study contributes to understand the causative mechanisms of Multiple System Atrophy. In particular, the observed impairment of respiratory chain activity, mitophagy and Coenzyme Q10 biosynthesis suggests that mitochondrial dysfunction plays a crucial role in the pathogenesis of the disease. Furthermore, these findings will hopefully contribute to identify novel therapeutic targets for this still incurable disorder.
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Authors
Giacomo Monzio Compagnoni, Giulio Kleiner, Andreina Bordoni, Francesco Fortunato, Dario Ronchi, Sabrina Salani, Marianna Guida, Corrado Corti, Irene Pichler, Christian Bergamini, Romana Fato, Maria Teresa Pellecchia, Annamaria Vallelunga,