| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10157693 | Matrix Biology | 2018 | 10 Pages |
Abstract
The latent transforming growth factor (TGF) β binding proteins (LTBP) are crucial mediators of TGFβ function, as they control growth factor secretion, matrix deposition, presentation and activation. Deficiencies in specific LTBP isoforms yield discrete phenotypes representing defects in bone, lung and cardiovascular development mediated by loss of TGFβ signaling. Additional phenotypes represent loss of unique TGFβ-independent features of LTBP effects on elastogenesis and microfibril assembly. Thus, the LTBPs act as sensors for the regulation of both growth factor activity and matrix function.
Keywords
LTBPLatent TGFβ binding proteinsarginylglycylaspartic acidlatent TGFβ binding proteinLLCAAAMFSTGFECMLAPMSCFGFTGFβRGDAneurysmAbdominal aneurysmtransforming growth factorEMTsmall interferingembryonic stemMesenchymal stem cellMarfan Syndromesulfhydrylfibroblast growth factorFibrillinExtracellular matrixlarge latent complex
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Authors
Daniel B. Rifkin, William J. Rifkin, Lior Zilberberg,