Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10157746 | Pathology - Research and Practice | 2018 | 17 Pages |
Abstract
The aim of the study was to investigate whether microvessel density (MVD) could be associated with skeletal extramedullary disease relapse (skeletal-EMDR) in patients with multiple myeloma (MM) who have skeletal-EMD at diagnosis. Seventy-nine newly diagnosed MM patients who have skeletal-EMD were retrospectively enrolled in this study. The 4-year cumulative incidence of skeletal-EMDR was 35.0%±8.3%. The 4-year probability of overall survival (OS) was 54.0%±7.6%. Multivariate analysis showed that skeletal-EMDR (HRâ=â4.144; 95% CI: 1.608-10.685; Pâ=â0.003) was independently associated with inferior OS for the MM patients who have skeletal-EMD at diagnosis. The factors associated with skeletal-EMDR were MVD (HRâ=â3.990, 95%CI:1.136-14.018; Pâ=â0.031), white blood cell (WBC) (HRâ=â0.262, 95% CI:0.090-0.769; Pâ=â0.015), and the EMD sites involved at onset (HRâ=â0.263, 95% CI: 0.074-0.937; Pâ=â0.039). The MVD in patients with thoracic and lumbar vertebrae as the involved sites at diagnosis was significantly lower than those with other sites involved (41.59â±â14.39 vs. 60.82â±â35.14, P=0.001). Our data suggest that increased MVD could be used to predict skeletal-EMDR, which is associated with inferior survival in patients with MM who have skeletal-EMD at diagnosis.
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Authors
Jian-Zhu Yang, Xian-Da Wu, Jian-Bo Meng, Jin-Qiao Zhang, Li-Xia Sun,