Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10157789 | Cytokine & Growth Factor Reviews | 2018 | 7 Pages |
Abstract
Innate lymphoid cells (ILCs) are immune cells that lack specific antigen receptors but possess similar effector functions as T cells. Concordantly, ILCs express many transcription factors known to be important for T cell effector function. ILCs develop from lymphoid progenitors in fetal liver and adult bone marrow. However, the identification of ILC progenitor (ILCP) and other precursors in peripheral tissues raises the question of whether ILC development might occur at extramedullary sites. We discuss central and local generation in maintaining ILC abundance at peripheral sites.
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Authors
Arundhoti Das, Christelle Harly, Qi Yang, Avinash Bhandoola,