Therapeutic opportunities based on caspase modulation

Article ID	Journal	Published Year	Pages	File Type
10157933	Seminars in Cell & Developmental Biology	2018	8 Pages	PDF

Abstract

Caspases are a family of proteolytic enzymes that play a critical role in the regulation of programmed cell death via apoptosis. Activation of caspases is frequently impaired in human cancers, contributing to cancer formation, progression and therapy resistance. A better understanding of the molecular mechanisms regulating caspase activation in cancer cells is therefore highly important. Thus, targeted modulation of caspase activation and apoptosis represents a promising approach for the development of new therapeutic options to elucidate cancer cell death.

Keywords

IRF NF-κB-inducing kinase caspase-activated deoxyribonuclease AML TNF SMAC TMZ NIK XIAP TNFR CLL FADD IAP NF-κB CDK HDAC 5-aza-2-deoxycytidine 5-Aza BIR cIAP HDACis mitochondrial outer membrane permeabilization interferon IFN cellular Inhibitor of Apoptosis Temozolomide Ring Apoptosis second mitochondria-derived activator of caspases Cancer CAD Interferon-regulatory factor tumor necrosis factor Nuclear factor-kappa B TRAIL acute myeloid leukemia Acute lymphoblastic leukemia Chronic lymphocytic leukemia TNF-related apoptosis-inducing ligand MOMP HDAC inhibitors Cell death inhibitor of apoptosis NAIP ALL histone deacetylase RIP Fas-associated protein with death domain Neuronal apoptosis inhibitory protein Receptor-interacting protein really interesting new gene Caspases cyclin-dependent kinase TNF receptor