Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10158573 | Pulmonary Pharmacology & Therapeutics | 2018 | 30 Pages |
Abstract
These results suggest an inhibitory role for MK2 and MK3 activity in RANTES/CCL5 secretion and cross-talk of MK3 with NF-κB to regulate IL-6 and GM-CSF. These findings differentiate MK2 and MK3 function in ASM cells and provide insight that may enable selective targeting of MKs in ASM to modulate local inflammation in airway disease.
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Authors
Mariam Ba, Shanti Rawat, Ronna Lao, Marilyn Grous, Michael Salmon, Andrew J. Halayko, William T. Gerthoffer, Cherie A. Singer,