Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10175601 | Journal of Orthopaedic Science | 2011 | 4 Pages |
Abstract
Osteopetrosis or marble bone disease is a disease of osteoclasts that results in a failure of bone remodeling [1]. It is a generalized skeletal disorder characterized by osteosclerosis, obliteration of the medullary cavity and fragility of the bones [2]. This malignant sex-linked recessive condition is associated with childhood problems and early death. However, the autosomal dominant form is compatible with a normal life span, and as many as 40% of patients may remain asymptomatic [3, 4].
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Authors
Motoki Sonohata, Masaaki Mawatari, Takao Hotokebuchi, Takatoshi Okubo, Haruko Ono,