The bisphosphonate ibandronate accelerates osseointegration of hydroxyapatite-coated cementless implants in an animal model

Continuous treatment with 5 μg/kg per day iban-dronate is potent in accelerating osseointegration of hydroxy-apatite-coated implants. As a result, improved early secondary stability and prevention of wear debris migration by the sealing of the implant-bone interface can be expected, therefore prolonging the long-term survival of the implant.