| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10213401 | International Journal of Cardiology | 2018 | 28 Pages |
Abstract
This proof-of-concept study using an in vitro experimental cell culture model identifies the protective role of simvastatin against TGF-β1-induced hVF transformation into activated myofibroblasts through activation of protein phosphatase, a novel target that can be therapeutically modulated to curb excessive cardiac fibrosis associated with maladaptive cardiac remodeling.
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Authors
Farhan Rizvi, Ramail Siddiqui, Alessandra DeFranco, Peter Homar, Larisa Emelyanova, Ekhson Holmuhamedov, Gracious Ross, A. Jamil Tajik, Arshad Jahangir,