Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10213535 | International Journal of Cardiology | 2018 | 6 Pages |
Abstract
During in vitro cardiac maturation, we observed a metabolic shift to fatty acids, which are known as a main energy source of mammalian hearts, suggesting hi-PSC-CM as a potential functional phenotype to investigate alteration of cardiac metabolism in cardiac diseases. Results also highlight the use of available clinical nuclear medicine tracers as functional assays in stem cell research for improved generation of autologous differentiated cells for numerous biomedical applications.
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Authors
Naoko Nose, Rudolf A. Werner, Yuichiro Ueda, Katharina Günther, Constantin Lapa, Mehrbod S. Javadi, Kazuhito Fukushima, Frank Edenhofer, Takahiro Higuchi,