Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10215297 | Brain and Development | 2018 | 6 Pages |
Abstract
This is the first report of SMC(15) with monocentric and duplicated proximal 15q. The clinical presentations are quite similar to those of isodicentric chromosome 15 syndrome. The results of microsatellite and SNP array analysis suggest two possibilities regarding the timing of the mosaic SMC(15) formation. One possibility is that it occurred during maternal meiosis, and the other possibility is formation during a very early stage of embryo development that was initially trisomic of chromosome 15.
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Authors
Kiyotaka Isobe, Hiroshi Matsumoto, Yoshiteru Tamura, Junya Hashimoto, Keiko Matsubara, Shigeaki Nonoyama,