Article ID Journal Published Year Pages File Type
10215297 Brain and Development 2018 6 Pages PDF
Abstract
This is the first report of SMC(15) with monocentric and duplicated proximal 15q. The clinical presentations are quite similar to those of isodicentric chromosome 15 syndrome. The results of microsatellite and SNP array analysis suggest two possibilities regarding the timing of the mosaic SMC(15) formation. One possibility is that it occurred during maternal meiosis, and the other possibility is formation during a very early stage of embryo development that was initially trisomic of chromosome 15.
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Life Sciences Neuroscience Developmental Neuroscience
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